Daily image guidance as a noninvasive technique of rectal emptying in postprostatectomy radiation

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Disclosure: This research was presented in part at the ASTRO 55 Annual Meeting, Sept. 22-25, 2013, Atlanta, GA.

Abstract

Objective: To present a novel approach of rectal emptying with image-guidance in prostate bed radiation therapy.

Methods and Materials: From July 2011 to December 2012, 86 consecutively treated postprostatectomy prostate cancer patients with no evidence of metastatic disease received adjuvant/salvage radiation to 70 Gy in 35 fractions with volumetric-modulated arc radiation therapy. Prior to simulation, an enema was performed to optimize rectal anatomy for treatment planning. Daily treatment protocol consisted of a cone-beam computed tomography (CBCT) for patient setup utilizing the most caudal surgical clip and bony anatomy; if the daily rectal volume overlapped the planning target volume (PTV) by ≥ 1 cm in any axial plane on CBCT, treatment was held and the patient was asked to empty his rectum. Repeat CBCT was obtained after voiding and prior to treatment delivery. Occasionally, patients were required to undergo repeated rounds of bowel emptying and CBCT. Each day a patient was required to void, all CBCTs taken on that day were contoured over the same cranio-caudal dimensions as the primary treatment plan. The contours were transferred to the original treatment planning CT, allowing us to compare the dose-volume histogram (DVH) of the distended rectum to the actual treated rectal contours.

Results: Twenty-nine (33.7%) of 86 patients had at least 1 fraction within their course of therapy in which the rectal volume overlapped the PTV by 1 cm. An average of 2.9 (8.3%) interventions were performed among the 29 patients. Rectal volumes and average cross-sectional area (CSA) after intervention demonstrate an almost 50% reduction in volume, and CSA of the rectum with reduced rectal V70 in each case.

Conclusions: Rectal emptying when rectal filling is noted on daily CBCT prior to radiation treatment is an easy intervention to implement. This practice is associated with reduced radiation dose to the rectum and may potentially decrease rectal toxicity.

Rectal toxicity is a common complication of prostatic bed radiation, resulting in symptoms such as diarrhea and rectal urgency and, less commonly, bleeding, ulceration, incontinence and rectovesical fistula. Interventions, including endorectal balloons, have been shown to reduce rectal toxicity but are invasive and often not well-tolerated by patients.1 Rectal emptying techniques such as laxatives, daily enemas, changes in fiber intake and antiflatulent agents have been employed to produce consistent rectal anatomy.2-14 Image-guided radiation therapy (IGRT) has enabled determination of shifts in patient position to accurately target the proper internal anatomy. Often, the treatment day anatomy, and specifically the planning target volume (PTV) and organs at risk (OAR), are positioned differently from what were originally planned, prompting efforts at adaptive radiation treatment planning, which involve substantial effort and resources.15

We present a novel approach using daily IGRT, which has been successful at our institution.

Methods and Materials

From July 2011 to December 2012, 86 consecutive patients were treated at our institution with prostate bed radiation therapy to 70 Gy in 35 fractions with volumetric modulated arc radiation therapy. All patients were instructed to have a full bladder for simulation, and an enema was performed to minimize rectal volume. Institutional protocol for treating the prostate bed includes use of daily cone-beam computed tomography (CBCT) for final patient positioning using bony anatomy and the most caudal surgical clips. If the visualized rectal volume overlapped the PTV by > 1 cm in any axial plane, treatment was held and the patient was asked to empty his rectal contents, gas or feces, while continuing to drink fluids to maintain maximum bladder volume. Generally, the patient was asked to use the lavatory and attempt to walk for 20-30 minutes to assist in bowel emptying prior to proceeding. The patient was then repositioned and reimaged with CBCT to verify appropriate rectal positioning relative to the PTV. Occasionally, patients required multiple cycles of bowel emptying before adequate rectal volumes (ie, < 1 cm overlap into the PTV) was achieved.

Data acquisition

All interventions were identified by chart review. The pre-emptying and postemptying CBCTs were coregistered with rigid registration, using bony anatomy and the most apical surgical clips. In the setting of multiple interventions to achieve appropriate rectal volumes, the last CBCT was considered the postemptying CBCT. Each CBCT rectum was physician contoured over the same cranio-caudal dimensions as the primary treatment plan. Institutional rectal volumes were followed, in which the rectum contour extends 3 mm superior and inferior to the PTV. The co-registered CBCTs from each daily treatment were then fused to the planning CT in the treatment planning software, Eclipse Treatment Planning System volume 8.9 (Varian Medical Systems, Palo Alto, California), using bony anatomy and the most caudal surgical clip.

Data analysis

To minimize the effect of outliers on the dose-volume histogram (DVH) analysis, patients requiring > 3 interventions throughout their treatment course were identified and reviewed. Rectal volumes and an average cross-sectional area (CSA) were calculated on the pre- and postemptying CBCTs. Average CSA was calculated by dividing the rectal volume by the cranio-caudal length of the rectum.

Results

Twenty-nine of the 86 treated patients underwent at least 1 intervention of rectal voiding during their course of treatment. For each patient, this occurred an average of 2.9 (8.3%) times. Five patients had > 3 interventions; these patients were reviewed for DVH comparison and had an average of 7 interventions (range 4 to 12); the results of the rectal DVH analysis are shown in Table 1. The pre-emptying V70 for each patient is close to or > 20 percent, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) threshold for 10% grade 3+ toxicity.16 The rectal volumes and calculated average CSA for pre- and postemptying as well as treatment planning volumes are shown in Table 2 and Table 3, and by both measures reduce volume and CSA of the rectum by almost 50%. Also, a comparison of bladder DVH and volumes are shown in Table 4.

For a single patient, axial and sagittal views of the CT simulation were created for visual representation of the interventions (Figure 1). Each intervention was demonstrated with the associated contours for pre-evacuation CBCT, and postevacuation CBCT contours shown as a compilation on the treatment planning CT.

Discussion

Daily changes in rectal anatomy are a concern during prostate bed radiation therapy; attempts to overcome these changes have included invasive procedures such as daily pretreatment enemas or endorectal balloons, as well as multiple dietary and pharmacologic interventions.2-14 We proposed the use of daily CBCT to minimize rectal distortion into the PTV. If the rectum distends into the PTV > 1 cm on any axial image, asking patients to empty their rectal contents while continuing to drink fluids to maintain maximum bladder volume is a simple, noninvasive and infrequent intervention to incorporate into clinical practice.

Previous investigators have reported daily interfraction motion and filling increases the overall radiation dose to the rectum when compared to the expected dose during treatment planning,17 while others have also reported more biochemical and local failures from variations in rectal distension.18-19 Numerous prospective studies have evaluated interventions to control daily rectal distension including: diet intervention, bowel relaxants, laxatives, rectal emptying via enema, self-evacuation with finger and rectal tubes.2-14 A systematic review of numerous rectal distension interventions was unable to find a superior intervention; however, techniques employing rectal emptying before treatment were shown to be effective in decreasing rectal volumes and prostate motion.20

Although the use of various techniques are employed to limit rectal distension, our technique reveals that it may not be necessary in all patients, as only 33% of patients required a single rectal emptying intervention following daily CBCT review of the rectum. However, in patients requiring the intervention, there is a dramatic effect on reducing rectal volumes to near treatment-planning volumes with minimal effect on the bladder. This has a potential effect on target coverage as rectal distension has been reported to cause distortions in both anterior-posterior (AP) and superior-inferior (SI) motion21-25 and this has also been seen in prostate bed patients.26 With this protocol, the target is covered more reliably, potentially improving control while reducing toxicity, a classic win-win situation.

The intervention of daily CBCT with rectal voiding if necessary may also have a behavioral effect on patients. Patients who have required multiple interventions have endeavored to cooperate with timing their bowel movements before their scheduled treatments. This change in behavior as well as an increase in bowel movement frequency during radiation therapy may reduce the need for interventions in the latter half of treatment.

We also considered drawing just the rectal wall instead of the entire rectal volume. Contouring the rectal wall increases relative dose; an absolute point dose would unlikely be helpful in this scenario as well. Contouring the complete volume to include feces and gas is more comparable to routine plan review and constraints seen in QUANTEC.16 When considering the artificial increase in relative dose due to decreased contour volume, it is also imperative to consider our institution protocol of contouring the rectal volume short in the cranio-caudal dimension; a small volume magnifies the relative dose-volume. With the challenges in comparing relative dose, we also reported CSA in attempts to decrease this variability and allow comparisons to historical data.

Conclusions

We have successfully implemented in our department a noninvasive approach to managing rectal filling during prostate bed radiation therapy using daily IGRT with CBCT. If IGRT with daily CBCT is to be utilized for prostatic bed IMRT, thought should be taken to review internal anatomy for abnormalities that could be easily augmented to parallel treatment planning volumes.

References

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Elliott DA, Nabavizadeh N, Tanyi JA, Hung AY.  Daily image guidance as a noninvasive technique of rectal emptying in postprostatectomy radiation.  Appl Rad Oncol.  2017;6(3):18-23.

About the Author

David A. Elliott, MD; Nima Nabavizadeh, MD; James A. Tanyi, PhD; and Arthur Y. Hung, MD

David A. Elliott, MD; Nima Nabavizadeh, MD; James A. Tanyi, PhD; and Arthur Y. Hung, MD

Dr. Elliott is assistant professor, Department of Radiation Medicine, University of Toledo, Toledo, OH. In the Department of Radiation Medicine, Oregon Health & Science University, Knight Cancer Institute, Portland, OR, Dr. Nabavizadeh, is assistant professor; Dr. Tanyi is associate professor, and Dr. Hung is assistant professor.

 



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