Partial breast IORT feasible long term for low risk patients

(*)Craniocaudal and medial lateral oblique mammographic views of the right breast demonstrating the index lesion of invasive ductal carcinoma in a patient who was clinically a candidate for APBI. (**) Breast MR image demonstrating the index lesion measuring approximately 1.4 cm in greatest dimension and showing an additional area of total enhancement measuring about 2.5 cm. (***)A breast MR image demonstrates an additional focus of cancer 5 mm in greatest dimension and 2.5 cm anteromedial to the biopsy-proven cancer.

August 2, 2013 – Long-term follow-up of partial breast intraoperative radiotherapy (IORT) technique given as the sole radiation treatment for patients with an excellent prognosis and very low recurrence risk was found feasible.

In a recent study, researchers evaluated 42 patients treated between 2004 and 2007. For inclusion in the trial the criteria for patients was ≥ 65 years old, T0-T1, N0, ductal invasive unifocal carcinoma, free-margin > 2 mm.  The treatment delivered on a linear accelerator consisted of one fraction of 21Gy and specified at the 90% isodose using electrons.

The results showed the 5 year-disease free survival was 92.7%, and all patients are still alive with a median follow-up of 72 months. The authors said the results confirm with a long-term follow-up that exclusive partial breast IORT is feasible for early-breast cancer in selected patients. They noted that IORT provides good late cosmetics results and should be considered as a safe and very comfortable “one-step” treatment procedure.

Reference:

Lemanski C, Azria D, Gourgou-Bourgade S, et al. Electrons for intraoperative radiotherapy in selected breast-cancer patients: late results of the Montpellier phase II trial. Radiat Oncol. 2013;8:191.

For more information: http://www.ro-journal.com/ and www.appliedradiationoncology.com 

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