August 2, 2013 – Long-term follow-up of partial breast intraoperative radiotherapy (IORT) technique given as the sole radiation treatment for patients with an excellent prognosis and very low recurrence risk was found feasible.
In a recent study, researchers evaluated 42 patients treated between 2004 and 2007. For inclusion in the trial the criteria for patients was ≥ 65 years old, T0-T1, N0, ductal invasive unifocal carcinoma, free-margin > 2 mm. The treatment delivered on a linear accelerator consisted of one fraction of 21Gy and specified at the 90% isodose using electrons.
The results showed the 5 year-disease free survival was 92.7%, and all patients are still alive with a median follow-up of 72 months. The authors said the results confirm with a long-term follow-up that exclusive partial breast IORT is feasible for early-breast cancer in selected patients. They noted that IORT provides good late cosmetics results and should be considered as a safe and very comfortable “one-step” treatment procedure.
Lemanski C, Azria D, Gourgou-Bourgade S, et al. Electrons for intraoperative radiotherapy in selected breast-cancer patients: late results of the Montpellier phase II trial. Radiat Oncol. 2013;8:191.