Happy autumn! We hope the shift in seasons and recent annual ASTRO meeting have motivated you to adopt some new techniques or approaches in patient care, research, education, or leadership. It’s an exciting time of year brimming with change.

We have a few changes of our own to share, namely that ARO is going green in 2025, transitioning to all-digital issues. In addition to offering PDFs of all journal articles, appliedradiationoncology.com will host a complete edition of each issue that can be digitally paged through, as we have done for many years. This move underscores our commitment to sustainability while continuing to provide the high-quality content our readers expect.

We also want to acknowledge and thank Farzan Siddiqui, MD, PhD, for his exceptional service and dedication to ARO for more than 10 years. Dr Siddiqui is rotating off our editorial advisory board as he assumes new leadership roles at ASTRO and Henry Ford Hospital. His contributions to both clinical practice and the development of our journal have been invaluable, and we celebrate his unwavering commitment to advancing the field of radiation oncology.

Change also underscores the theme of this issue’s Resident Voice column, Help Us Swim , which reflects on the intense demands of residency. This compelling editorial advocates for structured assessments and entrustable professional activities that would better equip future radiation oncologists. The goal: transforming an overwhelming residency experience into one that fosters deeper mastery and confidence.

We are also proud to feature Anal Squamous Cell Carcinoma (ASCC): From Standard Treatment to Personalized Therapy . This CME-approved article examines both the current standard-of-care and innovative, future approaches to managing ASCC including therapy de-escalation strategies and the exciting potential of integrating liquid biopsies and molecular biomarkers. This shift toward a personalized, biomarker-driven approach shows great promise in ASCC treatment.

Next, we present Viral-Mediated Hepatocellular Carcinomas (HCCs): A Review on Mechanisms and Implications for Therapy, a thorough examination of the pathogenesis of HCC. The article discusses the encouraging clinical outcomes seen with immunotherapy and radiation therapy for advanced HCC and explores the synergistic effects of immune checkpoint inhibitors combined with radiation.

Our issue also features a research article comparing 2 hypofractionation protocols for prostate cancer treatment. CHHiP vs PROFIT for Localized Prostate Cancer: A Retrospective Dosimetric Comparison of Organs at Risk discusses that while the CHHiP protocol involves more complex contouring and planning, it ultimately reduces toxicity in patients receiving moderately hypofractionated radiation therapy. These findings provide important data for radiation oncologists seeking to minimize side effects in prostate cancer treatment.

Another excellent article is Extracapsular Prostate Brachytherapy Using Iodine-125 for Intermediate and Selected High-Risk Prostate Cancer: Technical Notes . The authors describe an advanced brachytherapy technique that improves precision in prostate cancer treatment by combining ultrasound and fluoroscopy to optimize seed placement.

We feature several interesting case reports as well. Exploring the Rarity: A Case Report of Adenosquamous Carcinoma of the Nasal Cavity presents one of the few reported cases of this aggressive cancer, offering a detailed look at its histology and clinical management. Additionally, A Rare Case of Skull Base Phosphaturic Mesenchymal Tumor discusses a rare tumor associated with tumor-induced osteomalacia, highlighting diagnostic challenges and treatment strategies. Finally, A Rare Case of Mycosis Fungoides of the Scalp Treated With Electron-Beam Radiation Therapy reports on a case of cutaneous T-cell lymphoma, which is difficult to diagnose due to its similarities with more common skin conditions.

We hope this issue provides valuable insights and stimulates further exploration in our ever-changing field, one that makes a difference in the lives of many patients. Thank you, as always, for your continued support!