CHUV, CERN and THERYQ Collaborate on FLASH Radiotherapy Device

 

The Centre Hospitalier Universitaire Vaudois (CHUV) in Lausanne, Switzerland, the European Laboratory for Particle Physics (CERN) in Geneva, Switzerland, and THERYQ (ALCEN Group) have signed an agreement for the world-first development of a revolutionary FLASH radiotherapy device that will use very high energy electron (VHEE) radiation to treat cancers resistant to conventional treatments. The device, based on CERN technology, will be installed at CHUV.

This development represents a very important hope to increase the effectiveness of radiotherapy, for the greatest benefit of patients. By reducing irradiation to a few milliseconds, FLASH radiotherapy considerably reduces side effects while increasing the effectiveness on tumors.

The program benefits from the prior financial support of the ISREC Foundation, in partnership with the Biltema Foundation which, through an exclusive donation of CHF 25.8 million, makes this project possible.

The tripartite agreement covers collaboration on the development, planning, regulatory compliance and construction of the world's first radiotherapy device using the FLASH technique with very high energy electrons. THERYQ, part of ALCEN's Healthcare Division, will produce this unique device that uses a compact linear accelerator based on CERN technology. A special bunker will be built at the CHUV to accommodate this technology.

The device is expected to be operational within two years. The first clinical trials are planned for 2025.

This major development is part of the continuation of an innovative FLASH radiotherapy clinical transfer program initiated in 2020 between CERN and CHUV. The current phase is made possible by a prior funding from the ISREC Foundation, which announced in June 2021 that it would support the project with CHF 25.8 million through a donation from the Biltema Foundation. The ISREC and Biltema foundations have also supported the initial phases of the FLASH program with an initial contribution of CHF 1 million.

Professor Jean Bourhis, head of the Department of Radiation Oncology at CHUV, and his team have pioneered the method called FLASH, which has produced impressive results in pre-clinical animal studies. With a view to clinical transfer, a pilot project launched in 2020 at CHUV saw the installation of a first prototype named FLASHKNiFE, manufactured by THERYQ, which allows the FLASH treatment of tumors up to 3 cm deep.

Pr Bourhis says, "FLASH technology represents real hope for increasing the potential for curing cancers with radiation therapy, and the current stage will enable first crucial clinical developments in this area."

By integrating the innovative compact linear accelerator technology developed by CERN, the FLASHDEEP tool produced by THERYQ will use very high energy electron beams (VHEE) of 100 to 200 MeV, 10 to 20 times more powerful than those of FLASHKNiFE. This extra power will allow FLASH treatment of all types of cancers up to a depth of 20 cm.

CERN has responded to the challenge of producing a high dose of very high energy electrons in less than 100 milliseconds, required for FLASH radiotherapy, by designing a unique accelerator based on CLIC (Compact Linear Collider) technology. It will accelerate electrons to treat tumors up to 20 cm deep and will be compact enough to fit in a typical hospital campus.

Mike Lamont, CERN Director for Accelerators and Technology, said, "At CERN, part of our mission is knowledge transfer and we actively work to find applications of our breakthroughs outside the domain of particle physics for the benefit of society at large. This collaboration demonstrates how CERN technologies and expertise combined with strong partnerships with experts in other fields can really make an impact."

Walter Wuensch, Project Leader at CERN, said, "A clinical FLASH facility has been developed, with which large, deep-seated tumors are treated using high-energy electrons. The facility is based on accelerator technology developed for CLIC (Compact Linear Collider) to create a high performance and compact facility that can easily fit on a typical hospital campus."

VHEE FLASH technology has several advantages. High-energy electrons can be focused and oriented in a way that is almost impossible with X-rays, and radiotherapy devices based on CERN's electron accelerator technology will be significantly more compact and less expensive than current proton-based therapy facilities.

THERYQ, a spinoff of PMB-ALCEN, is an innovative medical technology company specializing in the design and production of radiotherapy machines incorporating linear accelerators. From the first studies in 2013 on the FLASH effect to the first patient with skin cancer successfully treated in 2019, THERYQ has supported the development of FLASH therapy, particularly through a long-standing partnership with CHUV. The company has developed FLASHKNiFE, for external or intraoperative FLASH radiotherapy (10 MeV), treating superficial or shallow tumors (up to 3 cm).

Ludovic Le Meunier, CEO of THERYQ, said, "THERYQ is honored to contribute its expertise and agility to this project, alongside CHUV and CERN. FLASHDEEP marks a therapeutic revolution, with the potential to significantly increase the number of patients living longer and cancer-free lives."

FLASHDEEP, designed in collaboration with CHUV and CERN and produced by THERYQ, will be the first device capable of treating any type of solid tumor up to a depth of 20 cm using VHEE FLASH technology. This device has the potential to expand the use of radiotherapy in oncology and unlock new treatments for patients with cancer, as well as decrease treatment cost.

After delivering the first unit to CHUV, THERYQ will include FLASHDEEP in its own product range.

Pr. Pierre-Marie Glauser, Chairman, the ISREC Foundation, added, "The ISREC Foundation is pleased to contribute to the development of FLASH technology, and has done so since 2016. This innovative and interdisciplinary project bringing together biologists, physicists and physicians in close collaboration fits perfectly with the Foundation's objectives of supporting research in translational oncology. Today, we are delighted to see the realization of this decisive step that will take the FLASH program to a new level of efficiency and implementation."