Three-Week Course of Radiation Safe and Effective in Early-Stage Breast Cancer

 

In patients with early-stage breast cancer who have a higher risk of having their tumors recur, a three-week course of radiation therapy is as safe and effective as four to six weeks. Delivering fewer, but higher, doses of radiation following lumpectomy, while concurrently delivering a radiation boost to the surgical site, led to similar outcomes as a longer course of treatment. The findings of NRG Oncology/RTOG 1005 trial (NCT01349322) will be reported at the American Society for Radiation Oncology (ASTRO) 2022 Annual Meeting.

The study can help guide treatment decisions for patients who qualify for breast-conserving therapy but face a higher risk of tumor recurrence due to slightly larger tumor size or other factors. Previous studies have shown a three-week course of radiation therapy is as safe and effective as conventional six-week therapy for patients with a low risk of tumor recurrence, but patients who are at higher risk for tumor recurrence need an additional radiation boost to the lumpectomy site. 

“Adding a radiation boost reduces the likelihood of tumor recurrence in the breast by 20 to 30%, but delivering that boost after hypofractionated radiation therapy adds another week to treatment. This can be challenging for patients who need to take time off work or travel long distances for treatment,” said principal investigator (PI) Frank A. Vicini, MD, FASTRO, a radiation oncologist and National Director of Research & Breast Care Services at GenesisCare. 

This trial sought to determine if the boost could be delivered just as effectively at the same time as the shortened treatment course without increasing side effects or causing cosmetic damage. “We wanted to know whether the results that we’ve seen with lower-risk disease really apply to people with higher-risk disease, who are the majority of patients we see in clinic,” said Dr Vicini. “And the answer is, they do. Three weeks of radiation after lumpectomy is just as effective for patients who have a higher risk of recurrence as it is for lower risk patients.”

Eligible participants in the trial included 2,262 people with early-stage breast cancer who had an elevated risk of local recurrence following lumpectomy. Risk factors included higher tumor grade (3 vs 1,2), older age (≥50), receipt of pre-surgical chemotherapy and estrogen-receptor-negative status. The median patient age was 55 years, and patients were treated at 276 different sites across the United States, Canada, Switzerland, Israel, Hong Kong, Japan, Republic of Korea, and Singapore. 

For the study, patients were randomized into two study groups. Those in the first group (n=1,124) received conventional whole breast radiation delivered over four to five weeks, followed by a sequential boost to the lumpectomy site delivered over six to seven days. Patients in the second group (n=1,138) received hypofractionated whole breast radiation delivered over three weeks, with the boost to the surgical site delivered concurrently over those three weeks. 

At a median follow-up of 7.3 years, there were 56 in-breast recurrences among nearly 2,300 study participants. The three-week treatment was found to be non-inferior to the longer treatment for the study’s primary endpoint, tumor recurrence in the breast (hazard ratio 1.32, 90% confidence interval 0.84-2.05, p=0.039). The five-year and seven-year recurrence rates were 1.9% and 2.6% following hypofractionated/concurrent boost treatment, compared to 2.0% and 2.2% following

conventional/sequential boost treatment.

There also were no significant differences in cosmetic appearance or side effects between the groups. Cosmetic outcomes at three years post-treatment were rated by physicians as excellent or good for 84% of patients in the hypofractionated/concurrent boost arm, compared to 86% in the

conventional/sequential boost arm. Severe (grade 3 or higher) side effects were uncommon for both groups, experienced by 3.5% of patients after shortened treatment and 3.3% after conventional treatment. 

“This approach cuts treatment time for these patients in half,” said Dr Vicini. “Now the comfort level is there to say to higher-risk patients, ‘I can offer you this option, and it works just as well.’”

Increased understanding of how to treat breast cancer and advances in treatment technologies are likely behind the low rates of recurrence and side effects, said Dr Vicini. “Through the years, the surgeries, the pathology reporting, the radiation, the chemotherapy – they’ve all gotten much better. We can deliver doses with much more sophistication. As a result, recurrence rates are going down as success rates are going up.”

This study also incorporated a multi-layered process for quality review across the hundreds of study sites. “Adding a concurrent radiation boost to whole breast treatment requires a high degree of sophistication, and we wanted to ensure that sites were able to deliver the concentrated doses accurately. All cases enrolled on the study were reviewed by one of the PIs,” said Dr Vicini.

Questions to be answered next for the research team include whether more patients, such as those whose cancer has spread to the lymph nodes, can benefit from the three-week approach, as well as whether treatment time can be shortened even further. Research from the United Kingdom, for example, is testing a one-week course of radiation for lower-risk patients.